NSAIDS induced GI mucosal injury
Elucidate the NSAIDS induced GI toxicity?
| Upper GI | Small Bowel | Colon |
|---|---|---|
| GORD
Subepithelial petechial haemorrhage Erosions Ulcers(stomach>Duodenum) Bleeding(stomach=duodenum) Perforation/obstruction |
Ulcers
Strictures Diaphragms Enteropathy |
Colitis
Ulcers Strictures Diverticular bleed or perforation Collagenous colitis Relapse of IBD |
Use of capsule endoscopy has revealed that NSAID plus PPI strategy does not effectively reduce the small bowel lesions that will occur with an NSAID in the small intestine.
12.5% of all GI events which occur with NSAIDs are found in the lower gastrointestinal tract. This proportion of events would not be effectively treated by the NSAID plus PPI strategy.
